TY  - JOUR
AU  - Elsherif, Eid
AU  - Elbaky, Tarek Abdel
AU  - Elserafy, Fatma
AU  - Elkady, Noha
AU  - Dawood, Marwa
AU  - Gaber, Mohamed Abdel
AU  - Badawy, Atef
AU  - Gharabawy, Mohamed El
PY  - 2016
TI  - β-catenin and SKP2 proteins as predictors of grade and stage of non-muscle invasive urothelial bladder carcinoma
JF  - Chinese Clinical Oncology; Vol 5, No 1 (February 29, 2016): Chinese Clinical Oncology
Y2  - 2016
KW  - 
N2  - Background: To evaluate the expression of beta-catenin (β-catenin) and SKP2 proteins in superficial bladder cancer cases and their correlation with tumor grade and stage.  Methods: After institutional review board approval, we retrospectively evaluated the expression of β-catenin and SKP2 proteins in tissue specimens from patients with non-muscle invasive bladder cancer (NMIBC) and compared their results with a cohort of chronic nonspecific cystitis’s. Then we and explored these markers association with tumor grade and stage.  Results: A total of 40 patients were retrospectively identified, 50% was NMIBC and the rest were chronic nonspecific cystitis. β-catenin was expressed in 18 (90%) patients of the NMIBC group in comparison to 14 (70%) of the control group with (P=0.1), while SKP2 protein was only expressed in NMIBC groups (P=0.03). A statistically significant correlation was identified between nucleocytoplasmic localization of β-catenin and SKP2 with tumor grade, stage.  Conclusions: β-catenin and SKP2 expression are providing promising results for differentiating higher grade and stage non muscle invasive bladder cancers.
UR  - https://cco.amegroups.org/article/view/9339