AB063. NF2 expression is linked to meningioma location and visual symptoms in Indonesian patients
Abstract

AB063. NF2 expression is linked to meningioma location and visual symptoms in Indonesian patients

Ery Kus Dwianingsih1, Rachmat Andi Hartanto2, Andre Stefanus Panggabean3, Alfian Rismawan3, Yeshua Putra Krisnugraha3, Christina Megawimanti Sianipar3, Rusdy Ghazali Malueka3

1Department of Anatomical Pathology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; 2Division of Neurosurgery, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; 3Department of Neurology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia

Correspondence to: Ery Kus Dwianingsih, MD, PhD. Department of Anatomical Pathology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Radiopoetro Building, Jl Farmako, Sendowo, Sinduadi, Kec. Mlati, Kabupaten Sleman, Daerah Istimewa, Yogyakarta 55281, Indonesia. Email: ery_malueka@ugm.ac.id.

Background: Meningioma is the most common type of primary central nervous system tumor. The development of meningioma is often influenced by the neurofibromin-2 (NF2) gene. Studies have demonstrated that the genetic profile of meningioma is linked to their location. However, it is currently unclear whether there is an association between NF2 expression and meningioma location in the Indonesian population.

Methods: This retrospective cross-sectional analysis included 153 histologically confirmed meningioma patients admitted to Dr. Sardjito General Hospital in Yogyakarta, Indonesia. The study utilized immunohistochemistry (IHC) staining to determine the NF2/Merlin expression. Meningioma locations were established using brain magnetic resonance imaging (MRI) or computerized tomography (CT) scans before surgery. The data on other variables were collected from medical records.

Results: Of all the patients, 118 (77.1%) tested positive for NF2/Merlin expression. The subjects in the study comprised 126 (82.4%) World Health Organization (WHO) grade I tumors and 27 (17.6%) WHO grade II and III tumors. The research showed that 85 (55.6%) of the tumors were located in the spheno-orbital region. The study found a significant association between NF2 positive expression and meningioma location in the spheno-orbital region [odds ratio (OR) 2.51, P=0.02]. Therefore, the patients who tested positive for NF2 had higher chances of visual impairment (P=0.04).

Conclusions: This study showed positive NF2 expression is associated with meningioma location in spheno-orbital and patients’ visual symptoms.

Keywords: Neurofibromin-2 expression (NF2 expression); meningioma; visual symptoms; location

Acknowledgments

Funding: None.

Footnote

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://cco.amegroups.com/article/view/10.21037/cco-24-ab063/coif). The authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013) and approved by the Institutional Review Board of the Faculty of Medicine Public Health and Nursing, Gadjah Mada University (IRB No. KE/FK/0878/EC/2023). Written informed consent was obtained from the patients.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the noncommercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

Cite this abstract as: Dwianingsih EK, Hartanto RA, Panggabean AS, Rismawan A, Krisnugraha YP, Sianipar CM, Malueka RG. AB063. NF2 expression is linked to meningioma location and visual symptoms in Indonesian patients. Chin Clin Oncol 2024;13(Suppl 1):AB063. doi: 10.21037/cco-24-ab063

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