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CCO Annual Report (2025)

We are glad to present a brief introduction of CCO’s progress in 2025 here. CCO has an international editorial board comprising 56 members from 14 countries, including USA (50%), China (9%), Italy (9%), Japan (7%), among others. CCO published 80 articles in 2025, including 18 Review Articles and 28 Original Articles in total. According to the Google Analytics, CCO journal website had all together 169,133 visitors worldwide and 366,280 pageviews in 2025.

AME and Wolters Kluwer aim to expand access to global medical research through new collaboration

The agreement broadens the reach of nearly 50 Open Access titles, contributing globally to over 5,000 articles

October 2, 2025 — Wolters Kluwer Health announced a new collaboration with AME Publishing Company, an Open Access publisher specializing in medical journals and books, headquartered in Hong Kong, China.

New Impact Factor for Chinese Clinical Oncology: 2.5

We are pleased to announce that the Chinese Clinical Oncology (CCO) has attained its latest impact factor for the 2024 citation year: 2.5.

Chinese Clinical Oncology 2024 CiteScore Released: 3

We are pleased to announce that the Chinese Clinical Oncology (CCO) has achieved its 2024 CiteScore: 3, ranking 251 out of 415 journals in the Oncology category. This milestone underscores our ongoing commitment to publishing impactful research in the field.

Interviews with Outstanding Authors (2025)

In 2025, many CCO authors make outstanding contributions to our journal. Their articles published with us have received very well feedback in the field and stimulate a lot of discussions and new insights among the peers.

Hereby, we would like to highlight some of our outstanding authors who have been making immense efforts in their research fields, with a brief interview of their unique perspective and insightful view as authors.

Interviews with Editorial Board Members

CCO features a distinguished editorial board, the members of which continue to instill the power of their expertise for the journal’s development. By launching this column, we are glad to introduce to you some of them in the form of interviews, in which they will share their unique career experiences and perspectives. We believe their insights will shed light on the knowledge of related fields.

Interviews with Guest Editors

Over the years, a number of CCO guest editors have made valuable contributions to the journal. This column features interviews with our guest editors, who graciously share their experience in scientific careers and provide insightful perspectives on the special series.

Reviewer of the Month (2025)

In 2025, CCO reviewers continue to make outstanding contributions to the peer review process. They demonstrated professional effort and enthusiasm in their reviews and provided comments that genuinely help the authors to enhance their work.

Hereby, we would like to highlight some of our outstanding reviewers, with a brief interview of their thoughts and insights as a reviewer. Allow us to express our heartfelt gratitude for their tremendous effort and valuable contributions to the scientific process.

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Vol 15, No 2 (April, 2026)

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Editorial Commentary

First-line fulvestrant vs. anastrozole in hormone receptor-positive advanced breast cancer: insights from the final FALCON trial results

Yuko Takahashi, Shogo Nakamoto, Maki Tanioka, Tadahiko Shien

Chinese Clinical Oncology

2026;

(2)

:22

(30 April 2026)

PDF Full Text (3) Peer Review File COI Form Open Access

First-line programmed death-1 blockade plus chemotherapy in low programmed cell death ligand 1 esophageal squamous cell carcinoma: beyond a single biomarker

Shigenori Kadowaki

Chinese Clinical Oncology

2026;

(2)

:23

(30 April 2026)

PDF Full Text (4) Peer Review File COI Form Open Access

Targeting metabolism in acute myeloid leukemia: the next therapeutic frontier?

Alain Mina, Amer M. Zeidan

Chinese Clinical Oncology

2026;

(2)

:24

(30 April 2026)

PDF Full Text (3) Peer Review File COI Form Open Access

Hormone therapy in younger women: reassessing risk narratives in the era of precision menopausal care

Auro Del Giglio

Chinese Clinical Oncology

2026;

(2)

:25

(30 April 2026)

PDF Full Text (2) Peer Review File COI Form Open Access

Eribulin and trastuzumab in early-line HER2-positive metastatic breast cancer: evaluating an active chemotherapy partner in an evolving treatment landscape

Hannah L. Chang, Irene M. Kang, Hope S. Rugo

Chinese Clinical Oncology

2026;

(2)

:26

(30 April 2026)

PDF Full Text (2) Peer Review File COI Form Open Access

Is rechallenge with CDK4/6 inhibitors beyond progression reasonable for patients with hormone receptor-positive and HER2-negative advanced breast cancer?—a commentary on the PALMIRA trial

Mai Shimura, Toru Mukohara

Chinese Clinical Oncology

2026;

(2)

:27

(30 April 2026)

PDF Full Text (8) Peer Review File COI Form Open Access

Original Article

Fos-related antigen 1 is required for Helicobacter pylori-induced inflammatory response in gastric epithelial cells through NF-κB pathway

Yang Yang, Shihe Shao

Chinese Clinical Oncology

2026;

(2)

:28

(30 April 2026)

PDF Full Text (3) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Short- and long-term outcomes after laparoscopic versus open total gastrectomy for stage 0–I gastric cancer: a multicenter, retrospective analysis

Fangyao Zhou, Zaisheng Ye, Chengbin Zheng, Zhaojun Zhang, Wenjun Xiong, Junjiang Wang, Weixian Hu, Jiabin Zheng, Bin Luo, Wei Wang, Yong Li, Luchuan Chen, Xingyu Feng

Chinese Clinical Oncology

2026;

(2)

:29

(30 April 2026)

PDF Full Text (7) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

TP63 drives TKI resistance in EGFR-mutant lung cancer via ferroptosis inhibition

Kehan Li, Jiane Liu, Wenjuan Wang, Guangmin Zhang, Lina Zhu, Linlin Liu, Xiaohui Xu

Chinese Clinical Oncology

2026;

(2)

:30

(30 April 2026)

PDF Full Text (8) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Impact of neoadjuvant chemotherapy vs. upfront surgery on survival in early-onset colorectal cancer—a single centre experience

Oluwabukunmi Modupe Salami, Hao Yi, Guangyi Liu, Yang Li

Chinese Clinical Oncology

2026;

(2)

:31

(30 April 2026)

PDF Full Text (7) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Genome-wide 5-hydroxymethylcytosine in circulating cell-free DNA reflects DNA methylation dynamics for non-invasive detection of early hepatocellular carcinoma

Junya Peng, Xu Pan

Chinese Clinical Oncology

2026;

(2)

:32

(30 April 2026)

PDF Full Text (6) Reporting Checklist Peer Review File COI Form Open Access

Review Article

Surgical management of pancreatic cancer: an overview

Daniel Chun Pong Kwok, Kenneth Siu Ho Chok

Chinese Clinical Oncology

2026;

(2)

:33

(30 April 2026)

PDF Full Text (3) Peer Review File COI Form Open Access

Small cell lung cancer: a therapeutic update in the era of immunotherapy and beyond—a narrative review

Andrés Barba, Sergio Martínez-Recio, Mikel Portu, Ana Maria Soto-Cambres, Juan Carlos Trujillo, Nuria Farré, Margarita Majem

Chinese Clinical Oncology

2026;

(2)

:34

(30 April 2026)

PDF Full Text (2) Reporting Checklist Peer Review File COI Form Open Access

A narrative review of the value of immunoinflammatory markers in the prognosis of endometrial carcinoma

Xinxin Yin, Haoyang Zhang, Sai Zhang

Chinese Clinical Oncology

2026;

(2)

:35

(30 April 2026)

PDF Full Text (4) Reporting Checklist Peer Review File COI Form Open Access

Claudin 18.2 testing in gastroesophageal and pancreatobiliary cancers: current status, clinical implications and challenges

Sun Mi Lee, Huamin Wang

Chinese Clinical Oncology

2026;

(2)

:36

(30 April 2026)

PDF Full Text (3) Peer Review File COI Form Open Access

Benign metastasizing leiomyoma: a systematic review of diagnosis, management, and outcomes

Karolina Karoń, Natalia Szczęsny, Krzysztof Piątkowski, Ewelina Bornio, Wojciech Grabowski, Hanna Plata, Monika Pałatyńska, Łukasz Karoń, Szymon Piątek

Chinese Clinical Oncology

2026;

(2)

:37

(30 April 2026)

PDF Full Text (3) Reporting Checklist Peer Review File COI Form Open Access

Advances and applications of liquid biopsy approaches in hepatopancreatobiliary (HPB) cancers: a literature review

Dina Hauptschein, Pedro Luiz Serrano Uson Junior, Mitesh J. Borad

Chinese Clinical Oncology

2026;

(2)

:38

(30 April 2026)

PDF Full Text (4) Reporting Checklist Peer Review File COI Form Open Access

Role of androgen receptor signaling in chemoresistance in urothelial cancer: a narrative review

Taro Akai, Gaku Yamamichi, Hiroshi Miyamoto

Chinese Clinical Oncology

2026;

(2)

:39

(30 April 2026)

PDF Full Text (4) Reporting Checklist Peer Review File COI Form Open Access

Advancing precision oncology through innovative and adaptive master protocol designs: statistical, operational, and regulatory perspectives

Jun Yin, Susan Geyer, Qian Shi, Bryan McComb, Courtney Henry, Jonathan Metts

Chinese Clinical Oncology

2026;

(2)

:40

(30 April 2026)

PDF Full Text (2) Peer Review File COI Form Open Access

Guidelines and Expert Consensus

Guidelines on the diagnosis and treatment of primary liver cancer (2011 edition)

Primary Liver Cancer Diagnosis Treatment Expert Panel

Published online: 01 September 2012

PDF Full Text (130587) Open Access

Review Article

Staging and response assessment in lymphomas: the new Lugano classification

Bruce D. Cheson

Published online: 30 March 2015

PDF Full Text (63118) Open Access

Review Article

Advanced magnetic resonance imaging in glioblastoma: a review

Gaurav Shukla, Gregory S. Alexander, Spyridon Bakas, Rahul Nikam, Kiran Talekar, Joshua D. Palmer, Wenyin Shi

Published online: 24 August 2017

PDF Full Text (56580) Open Access

Review Article

Intrahepatic cholangiocarcinoma: the AJCC/UICC 8^th edition updates

Andrew J. Lee, Yun Shin Chun

Published online: 31 October 2018

PDF Full Text (51244) Open Access

Review Articles

Percutaneous therapies of hepatocellular carcinoma—an update

Julius Chapiro, Jean-François Henri Geschwind

Published online: 16 December 2013

PDF Full Text (47530) Open Access

Review Articles

A review of hepatocellular carcinoma (HCC) staging systems

Somasundaram Subramaniam, Robin K. Kelley, Alan P. Venook

Published online: 16 December 2013

PDF Full Text (47121) Open Access

Review Article

Surgical margins in the management of extremity soft tissue sarcoma

Makoto Endo, Patrick P. Lin

Published online: 30 August 2018

PDF Full Text (46368) Open Access

Review Article

Primary extranodal B-cell lymphoma: current concepts and treatment strategies

Barbara Vannata, Emanuele Zucca

Published online: 30 March 2015

PDF Full Text (45028) Open Access

Review Articles

Colorectal cancer screening: are stool and blood based tests good enough?

Chung-Wah Wu, Joseph Jao-Yiu Sung

Published online: 10 January 2013

PDF Full Text (42485) Open Access

Review Article

Biliary tract cancers: epidemiology, molecular pathogenesis and genetic risk associations

Lorena Marcano-Bonilla, Essa A. Mohamed, Taofic Mounajjed, Lewis R. Roberts

Published online: 31 October 2016

PDF Full Text (37734) Open Access

Review Article

Classification of meningiomas—advances and controversies

Patrick N. Harter, Yannick Braun, Karl H. Plate

Published online: 20 July 2017

PDF Full Text (37652) Open Access

Review Article

BRAF, MEK and KIT inhibitors for melanoma: adverse events and their management

Elisabeth Livingstone, Lisa Zimmer, Julia Vaubel, Dirk Schadendorf

Published online: 01 September 2014

PDF Full Text (36582) Open Access

Review Article

Imaging of soft tissue sarcomas

Dakshesh B. Patel, George R. Matcuk Jr

Published online: 30 August 2018

PDF Full Text (36027) Open Access

Review Article on Ovarian Cancer

Epidemiology of ovarian cancer

Patricia Gaona-Luviano, Lourdes Adriana Medina-Gaona, Kassandra Magaña-Pérez

Published online: 18 August 2020

PDF Full Text (35983) COI Form Open Access

Review Article

The timing of breast and axillary surgery after neoadjuvant chemotherapy for breast cancer

Zahraa Al-Hilli, Judy C. Boughey

Published online: 01 June 2016

PDF Full Text (35628) Open Access

Review Article

Epidemiology of gallbladder cancer in India

Usha Dutta, Nikhil Bush, Dimple Kalsi, Priyanka Popli, Vinay K. Kapoor

Published online: 27 August 2019

PDF Full Text (35532) Open Access

Review Article

Percutaneous biliary interventions and complications in malignant bile duct obstruction

Hooman Yarmohammadi, Anne M. Covey

Published online: 31 October 2016

PDF Full Text (33372) Open Access

Review Article

Indications for adjuvant radiation therapy in breast cancer: a review of the evidence and recommendations for clinical practice

Cameron W. Swanick, Benjamin D. Smith

Published online: 01 June 2016

PDF Full Text (31709) Open Access

Review Article

Pathologic classification of “pancreatic cancers”: current concepts and challenges

Mohamed E. Mostafa, Ipek Erbarut-Seven, Burcin Pehlivanoglu, Volkan Adsay

Published online: 04 January 2018

PDF Full Text (31406) Open Access

Review Article on Neoadjuvant/adjuvant Treatment for Early Breast Cancer

Neoadjuvant treatment for HER2-positive breast cancer

Masahiro Takada, Masakazu Toi

Published online: 22 June 2020

PDF Full Text (30407) COI Form Open Access

Full Most Read article list >>

Original Article

Prostate carcinoma in transgenic Lewis rats - a tumor model for evaluation of immunological treatments

Laura E. Johnson, Jordan T. Becker, Jason A. Dubovsky, Brian M. Olson, Douglas G. McNeel

Review Article

The spectrum of clinical trials aiming at personalizing medicine

Christophe Le Tourneau, Maud Kamal, Marie Alt, Loic Verlingue, Vincent Servois, Marie-Paule Sablin, Nicolas Servant, Xavier Paoletti

Drug designs fulfilling the requirements of clinical trials aiming at personalizing medicine

Sumithra J. Mandrekar, Daniel J. Sargent

From genomic data analysis to drug development: a new generation of trials using molecular marker assessment in breast cancer

Sophie Doisneau-Sixou, Nadia Harbeck

Melanoma adjuvant therapy

Prashanth M. Thalanayar, Sanjiv S. Agarwala, Ahmad A. Tarhini

Genotyping of cutaneous melanoma

Isabella C. Glitza, Michael A. Davies

Treatment of KIT-mutated metastatic mucosal melanoma

Kevin B. Kim, Anas Alrwas

New approaches in primary central nervous system lymphoma

Eleanor Fraser, Katherine Gruenberg, James L. Rubenstein

Molecular and clinical implementations of ovarian cancer mouse avatar models

Amira A. Zayed, Sumithra J. Mandrekar, Paul Haluska

An overview of the design and conduct of the BATTLE trials

Suyu Liu, J. Jack Lee

Designing a definitive trial for adjuvant targeted therapy in genotype defined lung cancer: the ALCHEMIST trials

Ryan S. Alden, Sumithra J. Mandrekar, Geoffrey R. Oxnard

Risk- and response-adapted strategies for the management of Hodgkin lymphoma

Marcus Remer, Peter W. M. Johnson

Prognostic scores for brain metastasis patients: use in clinical practice and trial design

Vyshak Alva Venur, Manmeet S. Ahluwalia

Strategies for preservation of memory function in patients with brain metastases

Nicholas B. Dye, Vinai Gondi, Minesh P. Mehta

Management of neoplastic meningitis

Patrick Roth, Michael Weller

Design and statistical principles of the SHIVA trial

Xavier Paoletti, Bernard Asselain, Maud Kamal, Nicolas Servant, Philippe Huppé, Ivan Bieche, Christophe Le Tourneau

Autologous tracheal replacement for cancer

Dominique Fabre, Elie Fadel, Sacha Mussot, Frederic Kolb, Nicolas Leymarie, Olaf Mercier, Thierry Le Chevalier, Philippe G. Dartevelle

The staging value of sentinel lymph node biopsy for breast cancer: translating pathologic findings to clinical practice

Jean Bao, Cory Donovan, Alice Chung, Armando E. Giuliano

HER2-positive breast cancer, how far away from the cure?—on the current situation of anti-HER2 therapy in breast cancer treatment and survival of patients

Ning Liao

Training of breast surgical oncologists

Mediget Teshome, Henry M. Kuerer

The way to precision medicine of our team

Fengrui Xu, Xiaodi Wang, Zefei Jiang

Genetic testing for hereditary breast cancer in Asia—moving forward

Ava Kwong

Editorials

Can EGFR mutation status evolve with chemotherapy?

Eric S. Kim, David J. Stewart, Alok A. Khorana

Meta-Analysis

Risk of venous thromboembolism with the erythropoiesisstimulating agents (ESAs) for the treatment of cancer-associated anemia: a meta-analysis of randomized control trials

Ping Zhan, Qin Wang, Qian Qian, Li-Ke Yu

Review Articles

Prevention of colorectal cancer and dietary management

Ningqi Hou, Dezheng Huo, James J. Dignam

Stage II colon cancer

David N. Church, Rachel Midgley, David J. Kerr

Mining the ACCENT database: a review and update

Lindsay A. Renfro, Qian Shi, Daniel J. Sargent

Status of hepatocellular carcinoma in South Korea

Seung Kew Yoon, Hoo Geun Chun

Statistics in Oncology Clinical Trials

Adaptive randomized phase II design for biomarker threshold selection and independent evaluation

Lindsay A. Renfro, Christina M. Coughlin, Axel M. Grothey, Daniel J. Sargent

Adaptive clinical trial designs in oncology

Yong Zang, J. Jack Lee

Statistical aspect of translational and correlative studies in clinical trials

Herbert Pang, Xiaofei Wang

Updates on Surgical Oncology

Clinical trials in lung cancer surgery and research cooperation

Wen-Zhao Zhong, Hao-Ran Zhai, Yi-Long Wu

Below are the latest Chinese Clinical Oncology articles published online ahead of print publication.

Original Article

Efficacy and safety of TAS-102 followed by regorafenib or reverse sequence in later-line treatment of metastatic colorectal cancer: a systematic review and meta-analysis

Bannawich Sapapsap, Sirapratch Champarhorm, Anchana Pongpun, Nattapong Kanchana, Jittipon Tantivit, Nattawut Leelakanok

Published online: 26 April 2026

Journal Highlight more

The Chinese Clinical Oncology, indexed in MEDLINE/PubMed, ESCI, is an open-access, peer-reviewed medical journal, providing current and practical information on diagnosis, prevention and clinical investigations of cancer. Specific areas of interest include, but not limited to multimodality therapy, markers, imaging, tumor biology, pathology, chemoprevention and technical advances related to cancer.