Abstract
AB070. Roles of neutrophil to lymphocyte ratio in differentiating glioblastoma from brain metastasis
Rusdy Ghazali Malueka1, Rachmat Andi Hartanto2, Andre Stefanus Panggabean1, Alfian Rismawan1, Yeshua Putra Krisnugraha1, Christina Megawimanti Sianipar1, Kusumo Dananjoyo1, Ahmad Asmedi1, Ery Kus Dwianingsih3
1Department of Neurology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Sardjito General Hospital, Yogyakarta, Indonesia;
2Division of Neurosurgery, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Sardjito General Hospital, Yogyakarta, Indonesia;
3Department of Anatomical Pathology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Sardjito General Hospital, Yogyakarta, Indonesia
Correspondence to: Rusdy Ghazali Malueka, MD, PhD. Department of Neurology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Sardjito General Hospital, Jl. Kesehatan No. 1 Sekip Sinduadi, Yogyakarta 55284, Indonesia. Email: rusdy_gm@ugm.ac.id.
Background: Glioblastoma and brain metastasis are two types of brain tumors that have a significant impact on the global healthcare system, with high rates of morbidity and mortality. These tumors can be challenging to differentiate from each other, as they often present with similar symptoms and features on medical imaging. The purpose of this study was to investigate whether the neutrophil-to-lymphocyte ratio (NLR) could help distinguish between glioblastoma and brain metastasis.
Methods: This is a retrospective cross-sectional analysis that utilized medical records from six hospitals located in Yogyakarta, Indonesia from the period of 2016 to 2021. The study included patients who were diagnosed with glioblastoma and brain metastasis. Laboratory data was collected upon initial admission, and the diagnosis of glioblastoma and brain metastasis was based on a histopathological examination.
Results: This study included a total of 393 subjects, with the glioblastoma group comprising 121 subjects and the brain metastasis group comprising 272 subjects. The group with glioblastoma had a higher NLR (11.12±11.56 vs. 8.75±9.18, P=0.006) than the brain metastasis group. The area under the curve from the receiver operating characteristic analysis was 0.587 (95% confidence Interval: 0.528–0.647, P=0.006). An NLR value greater than 7.14 was found to have 55.4% sensitivity and 62.5% specificity in predicting glioblastoma.
Conclusions: According to this study, the NLR value of patients suffering from glioblastoma was significantly higher when compared to those with brain metastasis. This indicates that there is a higher degree of systemic inflammation in glioblastoma as compared to brain metastasis. Therefore, the NLR value can be a useful diagnostic tool to distinguish between glioblastoma and brain metastasis.
Keywords: Neutrophil-to-lymphocyte ratio (NLR); glioblastoma; brain metastasis; inflammation
Acknowledgments
Funding: This research was supported by the PDUPT Grant from the Indonesian Ministry of Education, Culture, Research, and Technology (No. 6512/UN1/DITLIT/DIT-LIT/PT/2021 to R.G.M.).
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://cco.amegroups.com/article/view/10.21037/cco-24-ab070/coif). This research was supported by the PDUPT Grant from the Indonesian Ministry of Education, Culture, Research, and Technology (No. 6512/UN1/DITLIT/DIT-LIT/PT/2021 to R.G.M.). The other authors have no conflicts of interest to declare.
Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013) and approved by the Medical and Health Research Ethics Committee (MHREC), Universitas Gadjah Mada (UGM), Indonesia (No. KE/FK/0878/EC/2023). Because of the retrospective nature of the research, the requirement for informed consent was waived.
Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the noncommercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.
Cite this abstract as: Malueka RG, Hartanto RA, Panggabean AS, Rismawan A, Krisnugraha YP, Sianipar CM, Dananjoyo K, Asmedi A, Dwianingsih EK. AB070. Roles of neutrophil to lymphocyte ratio in differentiating glioblastoma from brain metastasis. Chin Clin Oncol 2024;13(Suppl 1):AB070. doi: 10.21037/cco-24-ab070
