This issue covers many aspects of pancreatic cancer research such as the tumor microenvironment, patient-derived xenografts, the role of inflammation in the etiology of pancreatic cancer, molecular patterns of intraductal papillary mucinous neoplasm (IPMN) progression, sequencing of fine needle aspiration of pancreatic cancer. All those topics are closely related to the critical translational questions in pancreatic cancer. We sincerely wish our readers will enjoy reading this particular issue.