Vol 4, No 3 (September 25, 2015): Chinese Clinical Oncology (Clinical Trials in the Genome Era—Study Designs and Endpoints, Practical Considerations - Guest Editors: Daniel Sargent, Sumithra Mandrekar and Axel Grothey)

Preface

Introduction to special issue on biomarker-based clinical trial designs in oncology

Daniel J. Sargent, Sumithra Mandrekar, Axel Grothey

PDF Pages: 28 Full Text (2982) Open Access

Review Article

Statistical principles for omics-based clinical trials

Michael C. Sachs

PDF Pages: 29 Full Text (6385) Open Access

Molecular and clinical implementations of ovarian cancer mouse avatar models

Amira A. Zayed, Sumithra J. Mandrekar, Paul Haluska

PDF Pages: 30 Full Text (11149) Open Access

An overview of the NCI precision medicine trials—NCI MATCH and MPACT

Khanh Do, Geraldine O’Sullivan Coyne, Alice P. Chen

PDF Pages: 31 Full Text (18802) Open Access

Design and statistical principles of the SHIVA trial

Xavier Paoletti, Bernard Asselain, Maud Kamal, Nicolas Servant, Philippe Huppé, Ivan Bieche, Christophe Le Tourneau

PDF Pages: 32 Full Text (9705) Open Access

An overview of the design and conduct of the BATTLE trials

Suyu Liu, J. Jack Lee

PDF Pages: 33 Full Text (16428) Open Access

The ALTERNATE trial: assessing a biomarker driven strategy for the treatment of post-menopausal women with ER+/Her2− invasive breast cancer

Vera Jean Suman, Matthew J. Ellis, Cynthia X. Ma

PDF Pages: 34 Full Text (7318) Open Access

The FOCUS4 design for biomarker stratified trials

Richard Kaplan

PDF Pages: 35 Full Text (5670) Open Access

Lung-MAP—framework, overview, and design principles

Renata Ferrarotto, Mary W. Redman, David R. Gandara, Roy S. Herbst, Vassiliki A. Papadimitrakopoulou

PDF Pages: 36 Full Text (7763) Open Access

Designing a definitive trial for adjuvant targeted therapy in genotype defined lung cancer: the ALCHEMIST trials

Ryan S. Alden, Sumithra J. Mandrekar, Geoffrey R. Oxnard

PDF Pages: 37 Full Text (11148) Open Access

Biomarker-based trials in neuro-oncology

Karla V. Ballman

PDF Pages: 38 Full Text (7299) Open Access

Disclosure:

The supplement “Clinical Trials in the Genome Era—Study Designs and Endpoints, Practical Considerations” was commissioned by the Editorial office, Chinese Clinical Oncology without any sponsorship or funding. Daniel Sargent, Sumithra Mandrekar and Axel Grothey served as the unpaid Guest Editors for the supplement.